Neuroprotective Effect of Resveratrol Against Glutamate-Induced Excitotoxicity
نویسندگان
چکیده
منابع مشابه
Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.
As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investiga...
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AIM To study the effects of KN-62, an inhibitor of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II), on the damage of cortical neurons and mechanisms of the loss of CCDPK II activity induced by sodium glutamate (Glu). METHODS CCDPK II activity was measured by 32P incorporation and backphosphorylations of endogenous proteins were studied by autoradiography. RESULTS 1) KN-62 provided ...
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The combination of memantine, an N-methyl-d-aspartate (NMDA) receptor antagonist, with an acetylcholinesterase inhibitor (AChEI) is the current standard of care in Alzheimer's disease (AD). Galantamine, an AChEI currently marketed for the treatment of AD, exerts memory-enhancing and neuroprotective effects via activation of nicotinic acetylcholine receptors (nAChRs). Here, we investigated the n...
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PURPOSE Glutamate is a major excitatory neurotransmitter in mammalian central nervous system. Excessive glutamate releasing overactivates its receptors and changes calcium homeostasis that in turn leads to a cascade of intracellular events causing neuronal degeneration. In current study, we used neural stem cells conditioned medium (NSCs-CM) to investigate its neuroprotective effects on glutama...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2015
ISSN: 1899-5276
DOI: 10.17219/acem/38144